The consequences of overtaking Western Pomerania under authority of Brandenburg loosen economic close ties of Slupsk with the Polish Kingdom. Additionally, Slupsk dwindled as the production centre after the Thirty - Year War. The crisis of alimentary craft had its own origin in loss of the city population, breaking market of urban recipients. The guild of millers, bated count of butcher's works broke up among other things. Later on, brewers had some problems with sell. Only after the Seven Years War the reconstruction of the Slupsk economy began. The history of textile production on the ground of the city was varied. The regulations limiting participation of village in trade shook the established position right-bank-centre of Old City. The big fire in 1718 had also its influence. Simultaneously, the activity of the textile production in the New City part of Slupsk followed. A curiosity from this period is so- called ‘House Of Compulsory Labor’, active in the New Gate in 1724÷1755. Beggars and tramps were employed there.

In the half of 18th century Slupsk became (second after Kolobrzeg) a woolen cloths producer. In 1782 there were 130 workshops of craftsmen from leather-branch. Thanks to that situation Slupsk became the greatest skinner centre on Pomerania. Craftsmen of metal-trade made about 8% of generality. The basic raw material was iron imported by sea from Sweden, most often taken in Ustka port. In 1692 two French immigrants, after Huguenot massacre, taking place into "St. Bartholomew's Day", settled in Slupsk. They found not large tobacco-manufactory, which was developed after 1800. Amber industry was traditionally craft with great significance for Slupsk inhabitants. After some problems of Thirty Year War time, favorable period came after 1726. The Prussian government made a decision holding up of Slupsk craftsmen in common with of Konigsberg (occupying hitherto monopolistic position). Because of that Slupsk inhabitants received a third of amber rinsed on the coast.

Towners possessed legal guarantees of fresh-water fishing and herrings fishing in the Baltic Sea. Salmon fishing in Slupia river were embraced a state monopoly. By the end of 17th century Slupsk possessed eleven villages and four granges. In 1807 a decree about abolition of personal serfdom peasantry let on flow of landless labor between a village and a city. However, the decisions made in 1810 and later in 1818 completely reorganized the obsolete system of mediaeval guild's monopoly in interest of open competition and production. A base of Slupsk economy in the beginning of 19th century was the craft work. Despite of the fact that in 1855÷1910 the number of the Slupsk population tripled, the number of craftsmen's stayed on near level and was about 630. The best years of Slupsk crafts work is the decade of 1880 when the number of all craftsmen's was over 900 people.

Slupsk became also commercial and financial centre. The branch of bank of Reich was situated in Slupsk; one of joint-stock private banks of Gdansk; district banking and credit institutions and Chamber of Commerce were also situated in Slupsk. The most important meaning had modern land communications network. The postal-military track Szczecin-Koszalin-Slupsk-Gdansk became in 1828÷1835 rebuilt on road. While 1836÷1837 a road Slupsk-Ustka was built. The railway line, built parallel from two directions, reached to Slupsk from Szczecin in 1869, from Gdansk direction in 1870. The railway connection Slupsk-Ustka was opened in 1878, and to Szczecinek and Poznan in 1879. Since 80s of 19th century, a domination of railway over Ustka’s port became a fact in Slupsk transport. In 1880-1918, in trans-shipments of goods made on Slupsk station, remained more or less double tonnage superiority with relation to port in Ustka.